I just passed this paralysis dust phase. I started out trying to get a hold of puffballs buying everyone i saw on ah and tried to farm them off walking trees in jugner with TH2. Drop rate was horrible. I was complaining to my LS when they told me the 3 eyed fish recipe. Idk about your server but in mine the fish were 2.5k each in jueno, and 4k in the outer cities. You get 2 dust instead of one. Use the three eyed fish recipe and you will break even if not profit a little bit when you sell potions and excess dust. I did dust to venom bolt heads, to potions. btw stack of potions sells for 19-22k and dust sells for about the same.
I'm not sure what crystal iDrewDogg was using, but i did Lightning+3eyedfish and got 2 paralysis dust. I was at 63 alchemy and failed several times. (4k for 1 fish with those failures=icky) I'd like to know how to get puffballs, gardening takes too long.
Opps... sry I didn't mean Lightning+3-eyed-fish = 2 puffballs. It is Lightning+3-eyed-fish = 2 paralysis dust. This has the same craft level requitments as the puffball decomposition. Sorry about the loses :o[